Product Name:
IKKb-NT
Product Number:
ab-nk076-5
Target Full Name: Inhibitor of nuclear factor kappa B kinase beta subunit
Target Alias: I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK2; IKKB; IKK-beta; NFKBIKB; IKBKINASE
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK076-6
Antibody Target Type: Pan-specific
Protein UniProt: O14920
Protein SigNET: O14920
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human IKKb (IkBKB) sequence peptide Cat. No.: PE-01BDH90
Antibody Immunogen Sequence: MSWSPSLTTQTSGAWEMKEC
Antibody Immunogen Description: Corresponds to amino acid residues M1 to E19; N-terminus
Production Method: Corresponds to amino acid residues M1 to E19; N-terminus
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 0.5 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 87-97 kDa.
Related Product 1: IKKb-NT blocking peptide
Related Product 2: IKKa-pT179+pS180 phosphosite-specific antibody (Cat. No.: AB-PK659)
Related Product 3: IKKb-BCT pan-specific antibody (Cat. No.: AB-NK076-5)
Related Product 4: IKKe-pS172 phosphosite-specific antibody (Cat. No.: AB-PK660)
Related Product 5: IKKSelectide - IKKa (CHUK) protein kinase substrate peptide
Related Product 6: IKKtide KinSub - IKK protein kinase substrate peptide
Scientific Background: IKKb (IKBKB) is a protein-serine/threonine kinase of the Other group and IKK family. It functions in NF-kappa-B signalling and is activated by various indicators of cellular stress, including inflammatory cytokines, bacterial or viral products, and DNA damage. The activity of the kinase enables for NF-kappa-B to enter the nucleus and stimulate the transcription of genes involved in the immune response, control of cell growth, and cellular protection against apoptosis. IKKb may be a tumour requiring protein (TRP), since it displays extremely low rates of mutation in human cancers.
