Product Name:
VEGFR3-1
Product Number:
ab-nk063-4
Target Full Name: Vascular endothelial growth factor receptor 3 ; Vascular endothelial growth factor receptor-protein-tyrosine kinase 3
Target Alias: Fms-related tyrosine kinase 4; PCL; Tyrosine-protein kinase receptor FLT4; FLT41; VEGFR3; VGFR3; VGR3; CCDS4457.1; ENSG00000037280
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK064-2
Antibody Target Type: Pan-specific
Protein UniProt: P35916
Protein SigNET: P35916
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Human VEGFR3 (Flt4) sequence peptide Cat. No.: PE-01AVP95
Antibody Immunogen Sequence: CNELYDIQLLPRKSLE
Antibody Immunogen Description: Corresponds to amino acid residues N227 to E241
Production Method: Corresponds to amino acid residues N227 to E241
Antibody Modification: Protein kinase pan-specific antibody
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 0.05% Thimerasol
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Antibody microarray
Antibody Dilution Recommended: 2 µg/ml for immunoblotting
Antibody Potency: Very strong immunoreactivity with recombinant human VEGFR3 on protein dot blots.
Antibody Species Reactivity: Human
Antibody Positive Control: The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 160-175 kDa.
Antibody Specificity: Very high
Antibody Cross Reactivity: Weak immunoreactivity on protein dot blots with recombinant human VGFR1, and no immunoreactivity with recombinant human VGFR2.
Related Product 1: VEGFR3-1 blocking peptide
Related Product 2: VEGFR3 pan-specific antibody (Cat. No.: AB-NK064-2P)
Related Product 3: VEGFR3-2 pan-specific antibody (Cat. No.: AB-NK064-3)
Related Product 4: VEGFR3-pY1068 phosphosite-specific antibody (Cat. No.: AB-PK853)
Scientific Background: VEGFR3 (Flt4) is a protein-tyrosine kinase of the TK group and VEGFR family. It is a receptor for vascular endothelial growth factors (VEGF) C and D that is essential in angiogenesis and vasculogenesis. It is activated by binding VEGF-C and VEGF-D, which induce dimerization and autophosphorylation. VEGFR3 plays critical roles in some lymphangiogenetic mechanisms in cancer and metastasis. It is expressed in acute myeloid leukemia and other types of cancer, and are related to tumour angiogenesis and efficacy of traditional therapies.
